A man has been charged with murdering his partner, following her disappearance more than a week ago.
More than 40 officers and specialist police staff are working on the case of Pamela Jackson, 55.
Adrian Muir, 50, from Halifax, West Yorkshire, has been charged with her murder.
Mrs Jackson, who is also known as Cris or Crissie, was reported missing on Thursday evening after her son, Joe, 21, became concerned.
A Durham Police spokesman said there has been no definite sighting of her since Saturday March 2 when she was last seen at her home in The Crescent, Chester-le-Street.
He said there had been no activity on her mobile phone for several days and her Facebook page had also not been updated in the same time.
Detective Superintendent Ken Donnelly said: "Our main focus is on finding Pamela and we have a number of actions to follow up in our continuing search for her."
Mrs Jackson does not drive and does not work due to health issues. She also has two other adult sons, Andrew and Christopher, police said.
The grandmother is described as petite and is 5ft tall, slim and with very long, black hair which is usually straight.
She has a black rose tattoo to the upper right arm and large Celtic style letters to the upper left arm and usually wears what is described as vintage-style clothing with rings and costume jewellery.
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