Between five and 15 people are believed to have been killed after an explosion ripped through a fertiliser plant in Texas.
More than half of the town has been evacuated and people are still being pulled from damaged buildings following the blast in West, near Waco.
It comes as looters began targeting parts of the town, and police warned those with no need to be in the area to stay away.
A victim from the West fertilizer plant explosion is wheeled into hospitalThe explosion - which the US geological survey said had a 2.1 magnitude - was so powerful that a nearby block of flats was destroyed and 130 residents of a local nursing home were injured.
Sergeant William Swanton, from Waco Police Department, said there were scenes of "extreme devastation".
"We're going house to house, business to business, and we're seeing quite a bit of devastation in the area of the plant.
An elderly woman is taken into a hospital in Waco, Texas"They're still pulling victims out, still bringing victims to triage.
"There may be firefighters that are unaccounted for and potentially a law enforcement officer as well."
He added that locals "are going to be in a state of recovery for a very long time".
Hundreds of people were injured by the explosionHe also said that a helicopter which was helping with the rescue operation was damaged.
The blast damaged as many as 75 homes, as well as a local school.
A number of people are also suffering from "respiratory distress due to chemical inhalation".
Firefighters check a destroyed apartment complex near the plantThe explosion happened shortly before 8pm local time on Wednesday and could be heard as far away as 45 miles.
A man filmed the initial fire, and captured the moment of the explosion on camera.
His child is heard shouting: "Dad, I can't hear, let's get out of here. I can't hear anything."
Smoke rises as water is sprayed on the remains of the plantThe dad says simply: "Oh my god."
Anhydrous ammonia is widely used as a fertiliser, but it is also a key component of many explosive devices.
West's mayor Tommy Muska, who is part of the team of local volunteer firefighters, said a number of his colleagues are unaccounted for.
This image shows the initial blast Pic: KWTX-TVHe told CNN: "It's like a nuclear bomb went off."
Texas Governor Rick Perry said: "Our thoughts and prayers are with the people of West, and the first responders on the scene."
Debby Marak told The Associated Press she noticed a lot of smoke coming from the area across town near the plant, which is near a nursing home.
She said she drove over to see what was happening, and when she got out of her car two boys ran towards her screaming that officials told them to leave because the plant was going to explode.
Moments later the blast happened.
"It was like being in a tornado," the 58-year-old said. "Stuff was flying everywhere. It blew out my windshield.
The injured are treated at a nearby sports field"It was like the whole earth shook."
Police officers have reportedly been transporting the injured to local hospitals in their patrol cars.
As many as a dozen helicopters have been sent to the West High School stadium where ambulances are waiting to transport victims to hospitals.
A photo from Twitter user @TitansHomer shows a destroyed apartment complexGlenn Robinson, chief executive of Hillcrest Baptist Medical Centre, in Waco, told CNN his hospital had received 66 injured people for treatment, including 38 who were seriously hurt.
He said the injuries included blast injuries, orthopedic injuries, large wounds and a lot of lacerations and cuts.
American Red Cross crews from across Texas are being sent to the site.
The number of people arriving in the town offering assistance has become a logistical problem in itself, emergency workers say.
They are also anticipating further disruption later, with heavy thunderstorms and potential tornadoes forecast in the area.
The explosion comes on the eve of the 20th anniversary of the Waco siege - a deadly confrontation between federal authorities and heavily armed locals.
The Dallas Morning News said that the fertiliser company previously reported to the US Environmental Protection Agency and local public safety officials that there was no risk of fire or explosion at the plant.
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