Israeli missiles have struck a military research centre near the capital Damascus, setting off explosions, Syrian state television has said.
The rockets were said to have hit a military research centre in Jamraya on the outskirts of the capital in the early hours of this morning.
The building was the target of an earlier Israeli strike in January.
Israeli radio is reporting the latest attack has been confirmed by a senior security official.
A Western intelligence source said "stores of Fateh-110 missiles that were in transit from Iran to Hezbollah" were the target.
Video footage uploaded online by activists shows a huge ball of fire rising into the night sky.
More of the unverified footage uploaded by activists A Syrian official has called the attack a "declaration of war" by Israel.
Deputy Foreign Minister Faisal al Mekdad told CNN the strike represented an alliance between Islamic terrorists and Israel.
He added that Syria would retaliate against Israel in its own time and way.
Iran has condemned the Israeli attack and urged countries in the region to stand against the action, the Fars news agency reported.
Meanwhile, hundreds of families are fleeing a Syrian coastal area where activists say government troops have massacred nearly 200, many of them women and children.
Protests in Banias at the beginning of the uprising in 2011 Opponents of Bashar al Assad's regime say that fighters loyal to the President carried out two massacres on Saturday night and on Thursday in a Sunni Muslim area driven by a policy of ethnic cleansing.
Activists posted a video online of the bodies of 10 people it said were killed in Ras al Nabaa in the city of Banias, in an overnight attack.
The activists said half of the victims were children and that the number of deaths could be as high as 60.
It comes just two days after pro-Assad militias are alleged to have killed as many as 100 Sunnis in the nearby village of Baida.
Amateur video showed a man and at least three children dead inside a room.
A baby had burned legs and its body was covered in blood. Next to him was a young girl whose face had been deformed after apparently being hit with sharp metal.
Syria's crisis has claimed the lives of an estimated 70,000 people Other footage from activists showed entire families killed in their beds. A dead woman is seen cradling a child in her arms and two toddlers lying next to them.
The videos have not been independently verified.
The crisis in Syria, which began in March 2011 with pro-democracy protests and later turned into a civil war that has killed an estimated 70,000 people, has largely evolved along sectarian lines.
The Sunni majority forms the backbone of the rebellion, while Mr Assad's minority Alawite sect, an offshoot of Shi'ite Islam, anchors the regime's security services and the military's officer corps.
Other minorities, such as Christians, largely support Mr Assad or are standing on the sidelines, fearing the regime's collapse would bring about a more Islamist rule.
It has been estimated as many as 4,000 people are fleeing from the predominantly Sunni southern parts of the Mediterranean city of Banias amid fears of further large-scale killings.
The US has condemned the attack on Thursday. State Department spokeswoman Jennifer Psaki said: "We strongly condemn atrocities against the civilian population and reinforce our solidarity with the Syrian people."
She added: "The United States is appalled by horrific reports that more than 100 people were killed May 2 in gruesome attacks on the coastal town of Bayda, Syria.
"Regime and Shabiha forces reportedly destroyed the area with mortar fire then stormed the town and executed entire families, including women and children."
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